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Research at the Clinical Center

Published Clinical Research Conducted at the Clinical Center

The NIH Clinical Center is the world’s largest hospital entirely devoted to clinical research. It is a national resource that makes it possible to rapidly translate scientific observations and laboratory discoveries into new approaches for diagnosing, treating, and preventing disease.

Over 1,600 clinical research studies are conducted at the NIH Clinical Center, including those focused on cancer, infectious diseases, blood disorders, heart disease, lung disease, alcoholism and drug abuse.

Here is a sample of abstracts from the clinical research conducted at the NIH Clinical Center and published in a peer reviewed medical journal this year. Links to the full text and video formats are provided if available.


computerized x-ray imaging

Automated CT Biomarkers for Opportunistic Prediction of Future Cardiovascular Events and Mortality in an Asymptomatic Screening Population

Published in: The Lancet Digital Health (March 2020)

Computerized x-ray imaging often contains unused biometric data that artificial intelligence can access and analyze to predict major cardiovascular events including heart attack, stroke, and death and overall survival with higher accuracy than routine clinical examinations.

Read the article.


machine learning algorithm

A Machine Learning Algorithm to Estimate Sarcopenia on Abdominal CT

Published in: Academic Radiology (March 2020)

A prototype of a fully-automated deep learning system to detect central sarcopenia using computed tomography scans was successfully created and validated.

Read the article.


checkpoint inhibitor therapy

Checkpoint Inhibitor Therapy in Preclinical Sepsis Models: a Systematic Review and Meta-Analysis

Published in: Intensive Care Medicine Experimental (February 2020)

AA meta-analysis of 11 animal studies suggest that additional preclinical studies are needed to show the benefit that checkpoint inhibitors add to antibiotic therapy for common bacterial infections causing sepsis.

Read the article.



Chronic Mirabegron Treatment Increases Human Brown Fat, HDL Cholesterol, and Insulin Sensitivity

Published in: Journal of Clinical Investigation (January 2020)

A small study of healthy women treated for four weeks with a beta 3 adrenergic receptor agonist showed increases in metabolic activity of brown fat, HDL-cholesterol, insulin sensitivity, and bile acids, which help digest fats and regulate cholesterol.

Read the article.


ebola virus

Ebola Virus in the Democratic Republic of the Congo: Advances and Remaining Obstacles in Epidemic Control, Clinical Care, and Biomedical Research

Published in: Chest (January 2020)

The Ebola virus disease epidemic in the Congo remains uncontrolled with a high fatality rate despite advances in vaccine availability and use, improved clinical care within Ebola treatment units, and implementation of a research clinical trial evaluating targeted therapies.

Read the article.

NOTE: PDF documents require the free Adobe Reader.

This page last updated on 07/06/2020

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