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Research at the Clinical Center

Published Clinical Research Conducted at the Clinical Center

2019

Here is a sample of abstracts from the clinical research conducted at the NIH Clinical Center and published in a peer reviewed medical journal in 2019. Links to the full text and video formats are provided if available.

caring couple

Enhancing the Cancer Caregiving Experience: Building Resilience Through Role Adjustment and Mutuality

Published in: European Journal of Oncology Nursing (December 2019)

Coping with role adjustment and sustaining interpersonal connection, from cancer diagnosis through survivorship, is essential for a resilient relationship between a cancer patient and their primary family caregiver.

Read the article.

 

graphic featuring a microscope

Mobilization and Collection of Cells in the Hematologic Compartment for Cellular Therapies: Stem Cell Collection with G-CSF/Plerixafor, Collecting Lymphocytes/Monocytes

Published in: Seminars in Hematology (October 2019)

Mobilization and collection of donor or patient hematopoietic progenitor cells, lymphocytes, or monocytes are essential first steps in cellular therapy. G-CSF and plerixafor have improved collection yields, and apheresis technology provides a basis for optimizing collections.

Read the article.

 

Simulation training in the ICU

Simulation Training in the ICU

Published in: Chest (September 2019)

Since ICU patients require invasive procedures and efficient interprofessional team performance in a high-stakes environment, simulation is well-suited to safely train skills needed for ICU practice. This review evaluates the high-quality data regarding simulation in critical care training.

Read the article.

 

pills spilling out of a bottle

Evaluating the Risks of Public Health Programs: Rational Antibiotic Use and Antimicrobial Resistance

Published in: Bioethics (September 2019)

An ethical framework is proposed for evaluating public health programs that compromise the best clinical interests of present patients. This framework is applied and examined with programs that withhold or delay antibiotics in order to curb antimicrobial resistance.

Read the article.

 

cryopreservation

Effect of Cryopreservation on Autologous Chimeric Antigen Receptor T-Cell Characteristics

Published in: Molecular Therapy (July 2019)

At the NIH Center for Cellular Engineering, genetically modified immune cells that are frozen as soon as they are made and infused in patients immediately after being thawed are as clinically effective as genetically modified immune cells that are freshly made.

Read the article.

 

overweight man measuring waist

Ultra-Processed Diets Cause Excess Calorie Intake and Weight Gain: A One-Month Inpatient Randomized Controlled Trial of Ad Libitum Food Intake

Published in: Cell Metabolism (July 2019)

Researchers conducted the first randomized controlled trial to confirm that ultra-processed diets cause excess calorie intake and weight gain.

Read the article.

 

immunology

Immunology and Immunotherapy in Critical Care: An Overview

Published in: AACN Advanced Critical Care (June 2019)

The article provides a detailed description of how the human immune system works and how the different types of cancer immunotherapies interact with the immune system to produce benefits and side effects. This information will help guide the care of patients receiving immunotherapies.

Read the article.

 

doctor listening to a child's heartbeat

Understanding Long-Term Effects of Ebola Virus Disease

Published in: Nature Medicine (May 2019)

After year one of a five-year study, survivors of Ebola virus disease in West Africa had more memory loss, uveitis, and neurological, muscle, joint, chest, and abdominal abnormalities than the uninfected control group.

Read the article.

 

interventional radiology

Combined Locoregional-Immunotherapy for Liver Cancer

Published in: Journal of Hepatology (May 2019)

Interventional radiology and cancer immunology experts from the NIH Clinical Center and the NCI Center for Cancer Research pioneered the use of immune checkpoint blockade and minimally-invasive image guided procedures in patients with liver cancer and discuss outstanding issues to optimizing this multi-disciplinary treatment strategy.

Read the article.

 

group of people raising their hands

The Value of Engaging the Public in CHATing About Healthcare Priorities: A Response to Recent Commentaries

Published in: International Journal of Health Policy and Management (April 2019)

Responding to questions and comments on their study, Swiss-CHAT: Citizens Discuss Priorities for Swiss Health Insurance Coverage, the authors emphasize which citizens discussed complex issues and the validation of public participation in healthcare decisions.

Read the article.

 

man sleeping in MRI

Immunotherapy and the Interventional Oncologist: Challenges and Opportunities—A Society of Interventional Oncology White Paper

Published in: Radiology (April 2019)

An expert panel of immuno- and interventional oncologists discuss current and potential opportunities for immuno-oncology to be combined with interventional oncology to deliver improved or new benefits in the treatment of patients with cancer.

Read the article.

 

Native Americans

Constructing Identities: The Implications of DTC Ancestry Testing for Tribal Communities Gastric Cancer Syndrome

Published in: Genetics in Medicine (March 2019)

Issues are created for Native American communities when genetic ancestry companies promote the ability to determine Native American heritage and incorporate concepts of Native American race, ethnicity and group membership in marketing.

Read the article.

 

man holding head in pain

On Being the “Right” Kind of Chronic Pain Patient

Published in: Narrative Inquiry in Bioethics (March 2019)

The challenges experienced by 12 Americans living with chronic pain during an opioid epidemic and the sharp health disparities in chronic pain management are explored.

Read the article.

 

euthanasia or assisted suicide

Euthanasia and Assisted Suicide of Persons With Psychiatric Disorders: the Challenge of Personality Disorders

Published in: Psychological Medicine (March 2019)

Researchers discuss the evaluation process and challenges of Dutch patients with personality disorders who received euthanasia or assisted suicide based on thier psychiatric disorder.

Read the article.

 

computer displaying vitals

Epidemiology of Shock in Contemporary Cardiac Intensive Care Units

Published in: Circulation: Cardiovascular Quality and Outcomes (March 2019)

A multicenter evaluation of patients in North American cardiac intensive care units confirm a shift in the predominant underlying cause of cardiogenic shock - the most severe form of acute heart failure - to cardiovascular conditions other than acute heart attack.

Read the article.

 

double helix

The Phylogeny of 48 Alleles, Experimentally Verified at 21 kb, and Its Application to Clinical Allele Detection

Published in: Journal of Translational Medicine (February 2019)

Researchers pioneered the discovery and description of 4,243 different forms of a gene which, in this large number, can improve the accuracy of identifying the two forms of the gene present in every person and to improve precision diagnostics in patients.

Watch the video. Read the article.

 

bacterial culture

External Validation of Difficult-to-Treat Resistance Prevalence and Mortality Risk in Gram-Negative Bloodstream Infection Using Electronic Health Record Data from 140 US Hospitals

Published in: Open Forum Infectious Diseases (February 2019)

Electronic health records confirmed a previous finding from administrative datasets that patients with gram-negative bloodstream infections that are resistant to all first-line antibiotics are associated with higher mortality risk compared to those where one or more first-line antibiotics are active.

Read the article.

 

x-ray of chest cavity

Establishing a Center of Excellence for Hereditary Diffuse Gastric Cancer Syndrome

Published in: Journal of Surgical Oncology (January 2019)

A new program at the NIH Clinical Center for patients with hereditary gastric cancer syndromes incorporates comprehensive high-quality medical care and clinical and basic science research in a highly integrated, multidisciplinary setting.

Watch the video. Read the article.

 

Read more articles about research at the NIH Clinical Center in 2019.

NOTE: PDF documents require the free Adobe Reader.

This page last updated on 07/16/2020

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