Department of Perioperative Medicine

Presentations

• Getting Older

• Lessons Learned

• Exercise - Why Me

Publications

• Sapio MR, Iadarola MJ, Loydpierson AJ, Kim JJ, Maric D, Mannes AJ. Dynorphin and Enkephalin Opioid Peptides and Transcripts in Spinal Cord During Peripheral Inflammatory Hyperalgesia and Allodynia. Manuscript in review.

• Sapio MR1, Kim JJ1, Loydpierson AJ1, Dragan Maric D,Goto T, Fernando A. Vazquez FA, Muhly WT, Mannes AJ, Iadarola MJ. Opioid and non-opioid neuronal opponent processes in spinal cord dorsal horn controlling hyperalgesia and pain sensitization. (Manuscript in preparation).

• Kim PS, Staats PS, Deer TR, Iadarola MJ, Mannes, AJ. Intrathecal Drug Delivery for Cancer Pain. Elsevier (in Press 2019).

• Benjamin J. Harrison1,2,3, Juw Won Park3,4, Cynthia Gomes2,5, Jeffrey C. Petruska2,5,6, Matthew R. Sapio7, Michael J. Iadarola7, Julia H. Chariker2,3, and Eric C. Rouchka3. Detection of Differentially Expressed Cleavage Site Intervals Within 3′ Untranslated Regions Using CSI-UTR Reveals Regulated Interaction Motifs. Front. Genet., 12 March 2019 | https://doi.org/10.3389/fgene.2019.00182251.

• Sapio MR, Iadarola MJ, LaPaglia DM, Lehky T, Thurm AE, Danley KM, Fuhr SR, Lee MD, Huey AE, Sharp SJ, Tsao JW, Yanovski JA, Mannes AJ, Han JC, Haploinsufficiency of the brain-derived neurotrophic factor (BDNF) gene is associated with reduced pain sensitivity. Pain, 2019 Feb 27. doi: 10.1097/j.pain.0000000000001485. [Epub ahead of print] PMID:30855519.

• Burbelo PD, Browne S, Holland SM, Iadarola MJ, Alevizos I. Clinical features of Sjögren's syndrome patients with autoantibodies against interferons. Clin Transl Med. Jan 3;8(1):1, 2019.

• Miao N, Mannes AJ. Case Report: Anesthetic management of moyamoya disease. CASA 2019.

• Burbelo PD, Keller JM, Iadarola MJ: Comprehensive Antibody Profiles as Personalized Indicators of Health and Disease. Discov Med, Discov Med. Oct;24(132):161-168, 2017.

• Raithel SJ, Sapio MR, Iadarola MJ, Mannes AJ. Thermal A-δ Nociceptors, Identified by Transcriptomics, Express Higher Levels of Anesthesia-Sensitive Receptors Than Thermal C-Fibers and Are More Suppressible by Low-Dose Isoflurane. Anesth Analg. Jul;127(1):263-266, 2018.

• Raithel SJ, Sapio MR, LaPaglia DM, Iadarola MJ, Mannes AJ. Transcriptional Changes in Dorsal Spinal Cord Persist after Surgical Incision Despite Preemptive Analgesia with Peripheral Resiniferatoxin. Anesthesiology. Mar;128(3):620-635, 2018.

• Sapio MR, Neubert JK, LaPaglia DM, Maric D, Keller JM, Raithel SJ, Rohrs EL, Anderson EM, Butman JA, Caudle RM, Brown DC, Heiss JD, Mannes AJ, Iadarola MJ. Pain control through selective chemo-axotomy of centrally projecting TRPV1+ sensory neurons. J Clin Invest. Apr 2;128(4):1657-1670, 2018.

• Hall BE, Prochazkova M, Sapio MR, Minetos P, Kurochkina N, Binukumar BK, Amin ND, Terse A, Joseph J, Raithel SJ, Mannes AJ, Pant HC, Chung MK, Iadarola MJ, Kulkarni AB. Phosphorylation of the Transient Receptor Potential Ankyrin 1 by Cyclin-dependent Kinase 5 affects Chemo-nociception. Sci Rep. Jan 19;8(1):1177, 2018.

• Yuan ZX, Majchrzak-Hong S, Keyes GS, Iadarola MJ, Mannes AJ, Ramsden CE. Lipidomic profiling of targeted oxylipins with ultra-performance liquid chromatography-tandem mass spectrometry. Anal Bioanal Chem. 2018 Sep;410(23):6009-6029.

• Burbelo PD, Teos LY, Herche JL, Iadarola MJ, Alevizos I. Autoantibodies against the Immunoglobulin-Binding Region of Ro52 Link its Autoantigenicity with Pathogen Neutralization. Sci Rep. Feb 20;8(1):3345. 2018

• Iadarola MJ, Sapio MR, Raithel SJ, Mannes AJ, Brown DC. Long-term pain relief in canine osteoarthritis by a single intra-articular injection of resiniferatoxin, a potent TRPV1 agonist. Pain. Oct;159(10):2105-2114, 2018.

• Iadarola MJ, Brown DC, Sapio MR, Mannes AJ. On the Threshold of a New Analgesic: Shaping a Novel Treatment for Osteoarthritis Pain. (Pain Research Forum, 2018).

• Aron J, Raitel S, Mannes AJ. Torus Palatinus and Airway Management. (Anesthesiology 2017).

• Ames N, Shuford R, Frey M, Wilson F, Sundaramurthi P, Gori D, Navaleza G, Phillips J, Mannes A, Moriyama B, Koziol B, Yang L, Wallen G. Music in the ICU, A randomized controlled trial evaluating the effects of music listening on surgical patients' opioid use and self-reported pain, distress and anxiety. Integr Med Insights. 2017 Jul 20;12:1178633717716455. doi: 10.1177/1178633717716455. eCollection 2017

• Blivis D, Haspel G, Mannes PZ, O'Donovan MJ, Iadarola MJ: Identification of a novel spinal nociceptive-motor gate control circuit in rat following A pain stimuli. elife May 24;6. pii: e23584, 2017. PMID: 28537555

• LaPaglia DM, Sapio MR, Burbelo PD, Thierry-Mieg J, Thierry-Mieg D, Ramsden CE, Iadarola MJ, Mannes AJ: RNA-Seq investigations of human post-mortem trigeminal ganglia. Cephalalgia Jan 1:333102417720216, PMID: 28699403, 2017.

• Iadarola MJ, Sapio MR, Wang X, Carrero H, Virata MLA, Sarnovsky R, Mannes AJ, FitzGerald DJ: Analgesia by Deletion of Spinal Neurokinin 1 Receptor Expressing Neurons Using a Bioengineered Substance P-Pseudomonas Exotoxin Conjugate. Molecular Pain Jan-Dec; 13:1744806917727657, 2017. PMID: 28814145

• Ramsden CE, Domenichiello AF, Yuan ZX, Sapio MR, Keyes GS, Mishra SK, Gross JR, Majchrzak-Hong S, Zamora D, Horowitz MS, Davis JM, Sorokin AV, Dey A, LaPaglia DM, Wheeler JJ, Vasko MR, Mehta NN, Mannes AJ, Iadarola MJ: A systems approach for discovering linoleic acid derivatives that potentially mediate pain and itch. Sci Signal. Aug 22;10(493), 2017. PMID: 28831021,

• Sidana A,Diaz A, Truong H, Siddiqui MM, Miao N, Shih J, Mannes AJ, Bratslavsky G, Linehan M, Metwalli AR. Postoperative elevation in creatine kinase and its impact on renal function in patients undergoing complex partial nephrectomy. International Urology and Nephrology. 2016.

• Luiz HV, Yu R, Wolf K, Miao N, Mannes AJ, Pacak K. The Author's Reply: inappropriate adrenoreceptor blockade prior to pheochromocytoma removal - 'A timely reappraisal'. (Letter) Clin Endocrinol 2016.

• Asare P, Chowdhury A, Rajah T, Poler A, Shah M, Guion P, Martin J, Driscoll K, Qianhong W, Mannes A, Nataraj C. A system for semi-automatic management of blood loss during surgery: Preliminary results. IEEE-NIH 2016 Special Topics Conference on Healthcare Innovations and Point-of-Care Technologies. (IEEE Healthcare Innovations, 2016).

• Sapio MR, Goswami SC, Gross JR, Mannes MJ, Iadarola, MJ: Transcriptomics Analyses of Genes and Tissues in Inherited Sensory Neuropathies. Experimental Neurology 283:375-395, 2016.

• Salas MM, Clifford JL, Hayden JR, Iadarola MJ, Averitt DL. Local Resiniferatoxin Induces Long-Lasting Analgesia in a Rat Model of Full Thickness Thermal Injury. Pain Med. 2016 Oct 29. pii: pnw260, 2016. PMID: 27794548

• Ktena Y, Ramstad Y, Baker EH, Sloan JL, Mannes AJ, Manoli I, Venditti CP. Propofol administration in methylmalonic acidemia and intracellular cobalamin metabolism disorders. JIMD, 2015.

• Iadarola MJ, Sapio MR, Mannes AJ. A new splice of life for the μ-opioid receptor. J Clin Invest. 2015.

• Kurochkina NA, Iadarola MJ. Helical assemblies: Structure determinants. J Theor Biol. 2015 Jan 19. pii: S0022-5193(15)00021-1. doi: 10.1016/j.jtbi.2015.01.012. PMID: 25613414

• Brown DC and Iadarola MJ: TRPV1 Agonist Cytotoxicity for Chronic Pain Relief: From Mechanistic Understanding to Clinical Application. In: TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use. A. Szallasi (Ed) Elsevier, pp 99-118, 2015.

• Brown DC, Agnello K, Iadarola MJ. Intrathecal resiniferatoxin in a dog model: efficacy in bone cancer. Pain,156(6):1018-24, 2015.

• Foster DC, Falsetta ML, Woeller CF, Pollock SJ, Song K, Bonham A, Haidaris CG, Stodgell CJ, Messing SP, Iadarola M, Phipps RP: Site-specific mesenchymal control of inflammatory pain to yeast challenge in vulvodynia afflicted and pain-free women. Pain. 156(3):386-396, 2015.

• Iadarola MJ, Sapio MR, Mannes AJ: A new splice of life for the μ-opioid receptor. J Clin Invest. 26:1-4, 2015.

• Brown JD, Saeed M, Do L, Braz J, Basbaum AI, Iadarola MJ, Wilson DM, Dillon WP. Local injection of TRPV1 agonist in the dorsal root ganglia decreases pain transmission in swine. Sci Transl Med. Sep 16;7(305):305ra145, 2015. PMID:26378245

• Kalra S, Burbelo PD, Bayat A, Ching KH, Thurm A, Iadarola MJ, Swedo SE: No Evidence of Antibodies against GAD65 and Other Specific Antigens in Children with Autism. Biochemica Biophysica Acta Clinical 4:81-84, 2015.

• Bayat, A. Burbelo PD, Browne S, Quinlivan M. Martinez B, Holland SM, Mannes AJ, Breuer J, Cohen JI, Iadarola MJ: Anti-cytokine autoantibodies in postherpetic neuralgia. J Transl Med. 2013(1):333, 2015.

• Koethe Y, Mannes A, Wood B. Image-guided Nerve Cryoablation for Post-thoracotomy Pain Syndrome. CVIR 843-846, 2014.

• Tobias M, Mannes AJ: Management of Postoperative and Other Acute Pain. In: The Intensive Care Unit Manual. Second edition. 2014 Elsevier, Philadelphia, PA.

• Santini S, Painter TO, Kaszas K, Gross J, Douglas JT, Day VW, Iadarola MJ: Constrained TRPV1 agonists synthesized via silver-mediated intramolecular azo-methine ylide cycloaddition of -iminoamides. Bioorganic Med Chem Letts 24:963-968, 2014.

• Mitchell K, Lebovitz EE, Keller JM, Mannes AJ, Nemenov M, Iadarola MJ: Nociception and inflammatory hyperalgesia evaluated in rodents using infrared laser stimulation after Trpv1 gene knockout or resiniferatoxin lesion. Pain 155(4):733-745, 2014.

• Heiss J, Iadarola M, Cantor F, Oughourli A, Smith R, Mannes A. A Phase I study of the intrathecal administration of resiniferatoxin for treating severe refractory pain associated with advanced cancer (Abstract). J Pain, 15(4) S67, 2014.

• Goswami SC, Thierry-Mieg D, Thierry-Mieg J, Mishra SK, Hoon MA, Mannes AJ, Iadarola MJ. Itch-associated peptides: RNA-Seq and bioinformatic analysis of natriuretic precursor peptide B and gastrin releasing peptide in dorsal root and trigeminal ganglia, and the spinal cord. Molec Pain, 10:44, 2014.

• Roberts ME, Kaminski D, Jenks SA, Maguire C, Ching K, Burbelo PD, Iadarola M, Rosenberg A, Coca A, Anolik J, Sanz I. Primary Sjögren's Syndrome is characterized by distinct phenotypic and transcriptional profiles of IgD+ unswitched memory cells. Arthritis Rheumatol. 66(9):2558-2569, 2014.

• Goswami SC, Mishra SK, Maric D, Kaszas K, Gonnella GL, Clokie SJ, Kominsky HD, Gross JR, Keller JM, Mannes AJ, Hoon MA, Iadarola MJ: Molecular signatures of TRPV1 lineage neurons revealed by RNA-Seq of mouse and rat transcriptomes. J Pain 15(12):1338-59, 2014.

• Heiss H, Iadarola M, Cantor F, Oughourli A, Smith R, Mannes A. A phase I study of the intrathecal administration of resiniferatoxin for treating severe refractory pain associated with advanced cancer. APS Conference, Tampa 2014.

• Shuford R, Ames N, Frey M, Wilson F, Sundaramurthi P, Gori D, Navaleza G, Phillips J, Mannes A, Moriyama B, Koziol B, Yang L, Wallen G. Music in the ICU: Testing an Integrative Modality for Reducing Pain, Anxiety, Distress and Opioid Use. 2014

• Bayat A, Kroin JS, Buvanendran A, Iadarola MJ, Mannes AJ. Autoantibody Profiling in Complex Regional Pain Syndrome Using Luciferase Immunoprecipitation System (LIPS) Assay. Neuroscience. Washington DC 2014.

• Gross JR, Ramsden CE, Goswami A, Kaszas K, Mannes AJ, Iadarola MJ. TRPV1 modulation by lipid-autacoids using transcriptomics, precursor fatty acids, and functional activation analyses. Neuroscience. Washington DC 2014

• Goswami SC, Gross JR, Prochanzkova M, Mannes AJ, Iadarola MJ. Systems view of axotomy with RNA-Seq analysis of Dorsal Root Ganglion, Dorsal Horn and Ventral Horn. Neuroscience. Washington DC 2014.

• Santini S, Painter TO, Kaszas K, Gross J, Douglas JT, Day VW, Iadarola MJ. Constrained TRPV1 agonists synthesized via silver-mediated intramolecular azo-methine ylide cycloaddition of α-iminoamides. Bioorganic Med Chem Letts 24:963-968, 2014.

• Mitchell K, Lebovitz EE, Keller JM, Mannes AJ, Nemenov M, Iadarola MJ: Nociception and inflammatory hyperalgesia evaluated in rodents using infrared laser stimulation after Trpv1 gene knockout or resiniferatoxin lesion. Pain 155(4):733-745, 2014.

• Heiss J, Iadarola M, Cantor F, Oughourli A, Smith R, Mannes A. A Phase I study of the intrathecal administration of resiniferatoxin for treating severe refractory pain associated with advanced cancer (Abstract). J Pain, 15(4) S67, 2014.

• Iadarola MJ and Gonnella GL: Resiniferatoxin for pain management: an interventional approach to personalized pain medicine. Open Pain Journal 6, (Suppl 1) 95-107, 2013.

• Bruehl S, Apkarian AV, Ballantyne JC, Berger A, Borsook D, Chen WG, Farrar JT, Haythornthwaite JA, Horn SD, Iadarola MJ, Inturrisi CE, Lao L, Mackey S, Mao J, Sawczuk A, Uhl GR, Witter J, Woolf CJ, Zubieta JK, Lin Y. Personalized medicine and opioid analgesic prescribing for chronic pain: opportunities and challenges. J Pain. 14(2):103-13, 2013.

• Burbelo PD, Swedo SE, Thurm A, Bayat A, Marques A, and Iadarola MJ: Lack of serum antibodies against Borrelia burgdorferi in children with autism. Clin Vaccine Immunol. May 8, 2013.

• Utreras E, Prochazkova M, Terse A, Gross J, Keller J, Iadarola MJ, Kulkarni AB: TGF-beta1 sensitizes TRPV1 through Cdk5 signaling in odontoblast-like cells. Mol Pain. 9(1):24, 2013.

• Burbelo PD, Ching KH, Morse C, Alevizos I, Bayat A, Cohen JI, Ali MA, Kapoor A, Browne S, Holland SM, Kovacs JA, Iadarola MJ: Altered Antibody Profiles against Common Infectious Agents in Chronic Disease. PLOS One. 8 (12): e81635, 2013.

• Iadarola MJ and Gonnella GL: Resiniferatoxin for pain management: an interventional approach to personalized pain medicine. Open Pain Journal 6, (Suppl 1) 95-107, 2013.

• Bruehl S, Apkarian AV, Ballantyne JC, Berger A, Borsook D, Chen WG, Farrar JT, Haythornthwaite JA, Horn SD, Iadarola MJ, Inturrisi CE, Lao L, Mackey S, Mao J, Sawczuk A, Uhl GR, Witter J, Woolf CJ, Zubieta JK, Lin Y. Personalized medicine and opioid analgesic prescribing for chronic pain: opportunities and challenges. J Pain. 14(2):103-13, 2013.

• Burbelo PD, Swedo SE, Thurm A, Bayat A, Marques A, and Iadarola MJ: Lack of serum antibodies against Borrelia burgdorferi in children with autism. Clin Vaccine Immunol. May 8, 2013.

• Utreras E, Prochazkova M, Terse A, Gross J, Keller J, Iadarola MJ, Kulkarni AB: TGF-beta1 sensitizes TRPV1 through Cdk5 signaling in odontoblast-like cells. Mol Pain. May 13, 9(1):24, 2013.

• Burbelo PD, Ching KH, Morse C, Alevizos I, Bayat A, Cohen JI, Ali MA, Kapoor A, Browne S, Holland SM, Kovacs JA, Iadarola MJ: Altered Antibody Profiles against Common Infectious Agents in Chronic Disease. PLOS One. 8 (12): e81635, 2013.

• E. Lebovitz, J. Keller, K. Kaszas, M. Iadarola, A. Mannes. Exploring the actions of TRPV1 positive allosteric modulators in a peripheral inflammation model. The Journal of Pain - April 2013 (Vol. 14, Issue 4, Supplement, Page S69)

• Mannes AJ, Kim PS, Lonser R. Neurosurgical Interventional Approaches to Pain in the 4th edition of Principles and Practice of Palliative Care and Supportive Oncology. 2012.

• Kaszas K, Keller JM, Coddou CA, Mishra SK, Hoon MA, Stojilkovic S, Jacobson KA, Iadarola MJ. Small molecule positive allosteric modulation of TRPV1 activation by vanilloids and acidic ph. J Pharmacol Exp Ther. 340(1): 152-160, 2012.

• Burbelo P, Bayat A, Lebovitz E, Iadarola M. New technologies for studying the complexity of oral diseases. Oral Dis. 18(2):121-126, 2012.

• Ching KH, Burbelo PD, Tipton, C, Wei C, Petri M, Sanz I, Iadarola M: Two Major Autoantibody Clusters in Systemic Lupus Erythematosus. PLoS ONE 7(2):e32001, 2012.

• Browne SK, Burbelo PD, Chetchotisakd P, Suputtamongkol Y, Kiertiburanakul S, Shaw PA, Kirk JL, Jutivorakool K, Zaman R, Ding L, Hsu AP, Patel SY, Olivier KN, Lulitanond V, Mootsikapun P, Anunnatsiri S, Angkasekwinai N, Sathapatayavongs B, Hsueh PR, Shieh CC, Brown MR, Thongnoppakhun W, Claypool R, Sampaio EP, Thepthai C, Waywa D, Dacombe C, Reizes Y, Zelazny AM, Saleeb P, Rosen LB, Mo A, Iadarola M, Holland SM. Adult-onset immunodeficiency in Thailand and Taiwan. New England J Med. 367(8):725-34, 2012.

• Burbelo PD, Dubovi EJ, Simmonds P, Medina JL, Henriquez JA, Mishra N, Wagner J, Tokarz R, Cullen JM, Iadarola MJ, Rice CM, Lipkin WI, Kapoor A. Serology-enabled discovery of genetically diverse hepaciviruses in a new host. J Virol. 86(11):6171-6178, 2012.

• Utreras E, Keller J, Terse A, Prochazkova M, Iadarola MJ, Kulkarni AB. Transforming Growth Factor-β1 Regulates Cdk5 Activity in Primary Sensory Neurons. J Biol Chem. 287(20):16917-16929, 2012.

• Burbelo PD, Kovacs JA, Wagner J, Bayat A, Rhodes CS, DeSouza Y, Greenspan JS, Iadarola MJ: the Cancer-associated virus landscape in HIV patients with oral hairy leukoplakia, Kaposi's sarcoma and non-Hodgkin lymphoma. AIDS Res Treatment. 634523, 2012.

• Lebovitz EE, Keller JM, Kominsky, H, Kaszas, K, Maric D, Iadarola MJ: Positive Allosteric Modulation of TRPV1 as a Novel Analgesic Mechanism. Molecular Pain 8:70, 2012.

• Burbelo PD, Lebovitz EE, Bren KE, Bayat A, Paviol S, Wenzlau JM, Barriga KJ, Rewers M, Harlan DM, Iadarola MJ: Extrapancreatic autoantibody profiles in Type I diabetes. PLoS ONE. 7(9): e45216, 2012.

• Burbelo PD, Bayat A, Wagner J, Nutman TB, Baraniuk JN, Iadarola MJ. No serological evidence for a role of HHV-6 infection in chronic fatigue syndrome. Am J Transl Res. 4(4):443-51, 2012.

• Nemenov M, Mitchell K, Keller J, Bates, B, Mannes A, Iadarola M. Cutaneous TRPV1- expressing A-delta and C-fiber neurons mediate behavioural withdrawal from noxious head or thermal tissue damage Montreal 2010.

• Coombes S, Mannes AJ, Stewart D. Use of intravenous and oral ketamine in pain management in NF1-associated glomus tumors: A case report. 2010 Children's Tumor Foundation (NF1) conference, Baltimore, 2010.

• Glossop N, Mannes A, Glynn L, Karanian J, Pritchard W, Chiesa A, Dittmar K, Wood B. CT/Ultrasound fusion for interventional pain manangement. ISURA 2010.