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Portrait of Andrew Mannes
Andrew Mannes, MD, ME, MBA

Chief, Perioperative Medicine


Perioperative Medicine


BS, University of Pennsylvania
ME, Dartmouth College
MBA, University of Maryland, University College
MD, George Washington University


Email: amannes@cc.nih.gov
Phone: 301-594-3427

Portrait of Andrew Mannes
Andrew Mannes, MD, ME, MBA

Chief, Perioperative Medicine


Perioperative Medicine


BS, University of Pennsylvania
ME, Dartmouth College
MBA, University of Maryland, University College
MD, George Washington University


Email: amannes@cc.nih.gov
Phone: 301-594-3427


Dr. Andrew Mannes has a long-standing interest in the treatment of severe pain often seen at the end of life.


Dr. Mannes is chief of the Clinical Center's Department of Perioperative Medicine. His current interests include developing pain therapies using gene therapy; targeting pain pathways with selective agonists, toxins, or fusion proteins; and improving the diagnosis of disease states using proteomic and genomic techniques.

He has written widely in books and medical journals on such topics as advances in cancer pain management, gene therapy for pain, and neurosurgical intervention approaches to pain relief. He is board certified in anesthesiology and fellowship-trained in pain management.

He collaborates with the Clinical Center's Pain and Palliative Care Service in the area of pain management and has also worked on treatment of chronic pain with investigators from several NIH intramural programs. He manages the Department of Perioperative Medicine laboratory which is focused on gaining insight into nociceptive and other sensory pathways to identify new approaches for treating pain.

Following completion of a Bachelor of Science degree in Bio-Engineering at the University of Pennsylvania and a Master of Engineering degree at Dartmouth College, Dr. Mannes received his MD degree at George Washington University. He completed a transitional internship at the Presbyterian Hospital of Philadelphia followed by an anesthesia residency at the Hospital of the University of Pennsylvania. While at University of Pennsylvania, he completed a fellowship in pain management and joined the Penn faculty as an Instructor in Anesthesiology in 1994. In 2019, he received his MBA degree from the University of Maryland, University College.

He was promoted to Assistant Professor of Anesthesiology in 1997 before coming to NIH. Dr. Mannes completed an NIH research fellowship in molecular biology in 1997. He has been in the Department of Anesthesia and Surgical Services since 2001.

Dr. Mannes is a member of the American Medical Association and is on the editorial advisory board of Open Pain Journal.

Book Chapters

Kim PS, Staats PS, Deer TR, Iadarola MJ, Mannes AJ. Intrathecal Drug Delivery for Cancer Pain. Elsevier (in Press 2019).

Tobias M, Mannes AJ: Management of Postoperative and Other Acute Pain. In: The Intensive Care Unit Manual. Second edition. 2014 Elsevier, Philadelphia, PA.

Mannes AJ, Kim PS, Lonser R. Neurosurgical Interventional Approaches to Pain in the 4th edition of Principles and Practice of Palliative Care and Supportive Oncology. 2012.

Mannes AJ, Kim PS, Lonser R. Neurosurgical Interventional Approaches to Pain in the 3rd edition of Principles and Practice of Palliative Care and Supportive Care. 2005.

Mannes AJ, Tobias MD, Lonser R. Neurosurgical and Interventional Approaches in Cancer Pain Management. In: Advances in Cancer Pain. Oncology Group, CMP Communications. 2004.

Yeoman D, Mannes AJ, Saitoh Y. Gene therapy for pain: Different approaches toward a common goal. In: Proceeding of the World Congress on Pain. 2003. IASP Press Seattle, WA.

Iadarola MJ, Lee S, Mannes AJ: Gene transfer approaches to pain control. In: Molecular Neurobiology of Pain. D. Borsook (Ed.) Progress in Pain Research and Management 9:337-359, 1997. IASP Press Seattle, WA.

Journal Articles

Lapaglia D, Sapio MR, Burbelo PD, Thierry-Mieg J, Thierry-Mieg D, Ramsden CE, Iadarola MJ, Mannes AJ. RNA-SEQ investigations of human postmortem trigeminal ganglia related to headache and migraine. (Cephalalgia 2018)

Raithel S, Sapio MR, Iadarola MJ, Mannes AJ. Thermal A-δ nociceptors, identified by transcriptomics, express higher levels of anesthesia-sensitive receptors than thermal C-fibers and are more suppressible by low-dose isoflurane. (Anesthesia and Analgesia 2018).

Raithel SJ, Sapio MR, LaPaglia DM, Iadarola MJ, Mannes AJ. Transcriptional changes in dorsal spinal cord persist after surgical incision despite preemptive analgesia with peripheral resiniferatoxin. Anesthesiology 2018.

Iadarola MJ, Sapio MR, Raithel SJ, Mannes AJ, Brown D. Long-term pain relief in a canine osteoarthritis model by a single intra-articular injection of resiniferatoxin, a potent TRPV1 agonist. (Pain 2018)

Iadarola MJ, Brown DC, Sapio MR, Mannes AJ. On the Threshold of a New Analgesic: Shaping a Novel Treatment for Osteoarthritis Pain. (Pain Research Forum, 2018).

Aron J, Raitel S, Mannes AJ. Torus Palatinus and Airway Management. (Anesthesiology 2017).

Ramden CE, Domenichiello A, Yan ZX, Sapio MR, Keyes GS, Mishra SK, Gross JR, Majchrsak-hong S, Zamor D, Horowitz MS, Davis JM, Sorokin AV, Dey A, LoPaglia DM, Wheeler JJ, Vasko MR, Mehta NN, Mannes AJ, Iadarola MJ. A systems approach for discovering linoleic acid derivatives that potentially mediate pain and itch. (Science Signaling 2017)

Guptill V, Cui X, Uehara Y, Horowitz, J, Middleton L, Khaibullina A, Mannes A, Iadarola M, and Quezado Z. Disruption of the transient receptor potential vanilloid 1 can affect survival, bacterial clearance, and cytokine gene expression during murine sepsis. Anesthesiology, 114 (5) pp. 1190-1199 2011.

Iadarola MJ, Mannes AJ: The Vanilloid Agonist Resiniferatoxin for Interventional-Based Pain Control. Current Topics in Drug Development, 1-9. 2011.

Soto E, Stewart DR, Mannes AJ, Ruppert SL, Baker K, Zlott D, Handel D, Berger AM. Oral Ketamine in the Palliative Care Setting: A Review of the Literature and Case Report of a Patient With Neurofibromatosis Type 1 and Glomus Tumor-Associated Complex Regional Pain Syndrome. Am J Hosp Palliat Care 2011.

Stewart D, Lee, Mannes, Moshyedi, Sloan, Yao, Legius. Diagnosis, management, and complications of glomus tumors of the fingers in neurofibromatosis type 1. J Med Genet 47:8 525-32 2010.

Bates, B, Mitchell K, Keller JM, Chan CC, Swaim WD, Yanskovich R, Mannes AJ, Iadarola MJ. Prolonged analgesic response of cornea to topical resiniferatoxin, a potent TRPV1 agonist Pain 149(3) 522-528 2010.

Mannes AJ, Shepherd M, Quezado Z. Resolution of diplopia with late treatment of post-dural puncture headache and intracranial hypotension. Can J Anes 2008.

Mannes AJ, Iadarola MJ. Potential downsides of perfect pain relief. Nature vol. 446: 24, 2007.

Mannes AJ, Iadarola MJ. Complete pain relief: potential problems and diagnostic solutions. Nature Clin Pract Neurol. 3 (12): 648-649 2007.

Mannes AJ, Grippo RJ, Chang R, Wood Bradford J. Case Study: Percutaneous Vertebroplasty as a Palliative Measure in Setting of Chronic Infection. J. Pain Sympt. (5):382-4 2006.

Brown, DC, Iadarola MJ, Perkowski SZ, Hardam ED, Shofer F, Karai L, Olah, Z, Mannes AJ. Physiologic and antinociceptive effects of intrathecal resiniferatoxin in a canine bone cancer model. Anesthesiology. 103(5) 1052-1059. 2005.

Mannes AJ, Brown DC, Keller J, Caudle RM, Cordes, Lauren L, Iadarola MJ, Meng QC. Measurement of Resiniferatoxin in Serum by High-performance Liquid Chromatography. J Chromatogr B Analyt Technol Biomed Life Sci. 823 (2) 184-8. 2005.

Mannes AJ, Martin B, Yang HY, Keller J, Lewin S, Gaiser R, Iadarola MJ. Cystatin C as a Cerebrospinal Fluid Biomarker for Pain in Humans. Pain 102(3) 251-6, 2003

Ferrante FM, King LF, Roche EA, Kim PS, Aranda M, DeLaney LR, Mardini IA, Mannes AJ: Radiofrequency sacroiliac joint denervation for sacroiliac syndrome. Reg Anesth Pain Med 26:137-142, 2001.

Polomano RC, Mannes AJ, Clark US and Bennett GJ. A Painful Peripheral Neuropathy in the Rat Produced by the Chemotherapeutic Drug, Paclitaxel. Pain 94(3) 293-304, 2001

Caudle RM, Mannes AJ: Dynorphin: Friend or foe? Pain 87:(3)235-239, 2000.

Mannes AJ, Caudle RM, O'Connell B, Iadarola MJ. Adenoviral Transfer of LacZ to Spinal Cord Neurons. Brain Research 793:1-6, 1998.

Caudle RM, Mannes AJ, Iadarola MJ. Activation of spinal kappa2 opioid receptors. Emerging Therapeutic Targets 1:109-112, 1997.


  • Clinical Center Nursing Award (Team Excellence Award), 2018
  • National Institutes of Health Clinical Center Director’s Award, 2016
  • NIH Director's Award for work on advancing resiniferatoxin to a successful IND approval, enabling its evaluation in clinical trials as a treatment for intractable pain, 2009
  • Hexagon Society (University of Pennsylvania), 1981

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This page last updated on 07/17/2019

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