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Medical Milestones - Clinical Center Firsts


  1. McCarthy CR. The origins and policies that govern institutional review boards. In: Emmanuel EJ, Lie RK, Grady C, et al. The Oxford Textbook of Clinical Research Ethics. New York, NY: Oxford University Press; 2008: 541-558.

  2. Hilbish TF. Developments in Diagnostic Radiology. Public Health Reports. 1954, 1020-27.

  3. Breacher G, Schniederman M, Williams GZ. Evaluation of electronic red blood cell counter. American J Clin Path. 1956, 26: 1439-49.

  4. Li MC, Hertz R, Bergenstal DM. Therapy of choriocarcinoma and related trophoblastic tumors with folic acid and purine agonists. N Eng J Med. 1958, 259: 66-74.

  5. Braunwald NS, Cooper T, Morrow AG. Complete replacement of the mitral valve. Successful clinical application of a flexible polyurethane prosthesis J Thoracic Cardiovasc Surg. 1960, 40: 1-11.

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  7. Kliman A, Gaydos LA, Schroeder LR, et al. Repeated plasmapherisis of blood donors as a source of platelets. Blood. 1961, 18: 303-9.

  8. Nirenberg, Marshall W. "The Genetic Code: II." Scientific American. 1963, 208: 80-94.

  9. Ommaya AK. Subcutaneous reservoir and pump for sterile access to ventricular cerebrospinal fluid. Lancet. 1963, 282: 983-84.

  10. Englander HR, Keyes PH, Getswicki M et al. Clinical anticaries effect of repeated topical sodium fluoride applications by mouthpieces. JADA. 1967, 75: 638–644.

  11. Doppman JL, Chiro DG. Subtraction-Angiography of Spinal Cord Vascular Malformations. J Nuerosurgery. 1965, 23: 440-43.

  12. Freirdreich EJ, Judson G, and Levin RH. Special collection of leukocytes. Cancer Res. 1965, 25: 1516-20.

  13. Chappell WS. Platelet Concentrates from Acidified Plasma: A Method of Preparation Without the Use of Additives. Transfusion. 1966, 6:308-9. 

  14. Doppman JL, Hammond WG, Melson GL, et al. Staining of parathyroid adenomas by selective arteriography. Radiology. 1969, 92, 527-530.

  15. Goodwin FK, Murphy DL and Bunney WE. Lithium-carbonate treatment in depression and mania. Arch Gen Psychiat. 1969, 21: 486-96.

  16. Lander JJ, Alter HJ, and Purcell RH. Frequency of antibody to hepatitis-associated antigen as measured by a new radioimmunoassay technique. J Immun. 1971, 106: 1166-71.

  17. Graw RG, Herzig G, Perry S, et al. Normal granulocyte transfusion therapy. NEJM. 1972, 287: 366-71.

  18. Gavin JR, Roth J, Jen P, et al. Insulin receptors in human circulating cells and fibroblasts. PNAS. 1972, 69: 747-51.

  19. Dinarello CA, Goldin NP, Wolff SM. Demonstration and Characterization of two distinct human leukocytic pyrogens. J Experimental Med. 1974, 139: 1369-80.

  20. Borer JS, Redwood DR, Levitt B, et al. Reduction in myocardial ischemia with nitroglycerin or nitroglycerin plus phenylephrine administered during acute myocardial infarction. NEJM. 1975, 293: 1008-12. 

  21. Lewis TL, and Macks GC. Adaptation of a general hospital computerized medical information system to the research hospital environment. Proc Annu Symp Comput Appl Med Care. 1977, Oct 5: 111-15.

  22. Dinarello CA, Refner L and Wolff SM. Human leukocytic pyrogen: purification and development of a radioimmunoassay. PNAS. 1977, 74:4624-27.

  23. Fauci AS, Katz P, Haynes BF. Cyclophosphamide therapy of severe systemic necrotizing vasculitis. NEJM. 1979, 301: 235-238.

  24. Buschbaum MS, Ingvar DH, Kessler R, et al. Cerebral glucography with positron tomography. Arch Gen Psychiatry. 1982, 39: 251-59.

  25. Steinherz R, Tietze F, Raiford D, et al. Patterns of amino acid efflux from isolated normal and cystinotic human leukocyte lysosomes. J Biol Chem. 1982, 257: 6041-49.

  26. Bowen DL, Lane HC, and Fauci AS. Immunopathogenesis of the acquired immunodeficiency syndrome. Ann Internal Med. 1985, 103:704-9.

  27. Weiss SH, Goedert JJ, Samgadharan MG, et al. Screening test for htlv-iii (aids agent) antibodies. JAMA. 1985, 221-25.

  28. Rosenburg SA, Lotze MT, Muul LM, et al. Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer. NEJM. 1985, 313:1485-92.

  29. Flament MF, Rapoport JL, Berg CJ. Clomipramine treatment of childhood obsessive-compulsive disorder. Arch Gen Psychiatry. 1985, 42:977-83.

  30. Castelli WP, Garrison RJ, Wilson PWF, Abbott RD et al. Incidence of coronary heart disease and lipoprotein cholesterol levels. JAMA. 1986, 256: 2835-38.

  31. Alexander DF. Why should there be an NICHD. Pediatrics. 2011, 127: 325 -333.

  32. Zbar B, Brauch H, Talmadge C, et al. Loss of alleles of loci on the short arm of chromosome 3 in renal cell carcinoma. Nature. 1987, 327: 721-24.

  33. Gahl WA, Reed GF, Thoene JG, et al. Cysteamine therapy for children with nephropathic cystinosis. NEJM. 1987, 316: 971-79.

  34. Mitsuya H, Weinhold, Furman PA, et al. 3’-azido-3’-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro. PNAS. 1985, 82: 7096-100.

  35. Yarchoan R Weinhold KJ, Lyerly HK, et al. Administration of 3’azido-3’-deoxythymidine, an inhibitor of HTLV-III/LAV replication, to patients with AIDS or AIDS-related complex. Lancet. 1986, 327: 575-80.

  36. Rosenburg SA, Packard BS, Aebersold PM. Use of tumor-infiltrating lympohcytes and interleukin-2 in immunotherapy of patients with metastatic melanoma. NEJM. 1988, 319: 1676-80. 

  37. Altschul SF, Gish W, Miller W, et al. Basic Local Alignment Search Tool. J Mol Biol. 1990. 215:403-10.

  38. Blaese RM, Culver KW, Miller D, et al. T Lymphocyte-directed gene therapy for ADA-SCID: initial trial results after 4 years. Science. 1995, 270: 475-80.

  39. Yarchoan R, Mitsuya H, Pluda JM, et al. The National Cancer Institute Phase I study of 2’, 3’-dideoxyinosine administration in adults with AIDS or AIDS-related complex: analysis of acticity and toxicity profiles. Rev of Infectious Diseases. 1990, 12 522-33.

  40. Barton NW, Brady RO, Dambrosia JM, et al. Replacement therapy for inherited enzyme deficiency—macrophage-targeted glucocerebrosidase for Gaucher’s disease. NEJM. 1991, 324: 1464-70.

  41. Latif FL, Tory K, Gnarra J, et al. Identification of the von Hippel-Lindau disease tumor suppressor gene. Science. 1993, 260: 1317-20.

  42. Kirnbauer R, Taub Jm Greenstone H, et al. Efficient self-assembly of human papillomavirus type 16 L1 and L1-L2 into virus-like particles. J Virology. 1993, 67: 6929-6936.

  43. Waldmann TA, White JD, Goldman Ck, et al. The interleukin-2 receptor: a target for monoclonal antibody treatment of human T-Cell lymphotrophic virus I-induced adult T-cell leukemia. Blood. 1993, 82:1701-1712.

  44. Frazier JA, Gordon CT, McKenna K, et al. An open trial of clozapine in 11 adolescents with childhood-onset schizophrenia. J Am Child Adolesc Psychiatry. 1994, 33:658-663.

  45. Rosenburg SA, Yanelli JR, Yang JC, et al. Treatment of patients with metastatic melanoma with autologous tumor-infiltrating lymphocytes and interleukin 2. J National Cancer Institute. 1994, 86: 1159-66.

  46. Martin DF, Parks DJ, Mellow SD, et al. Treatment of cytomegalovirus retinis with an intraocular sustained-release ganciclovir implant. Arch Ophthalmol. 1994, 112: 1531–39.

  47. Rosenfield SJ, Kimball J, Vining D, et al. Intensive immunosuppression with antithymocyte globulin and cyclosporine as treatment for sever acquired aplastic anemia. Blood. 1995, 85: 3058-65. 

  48. Swedo SE, Leonard HL, Garvey M, et al. Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: clinical description of the first 50 cases. Am J Psychiatry. 1998, 155: 264-71.

  49. Childs R, Chernoff A, Contentin N, et al. Regression of Metastatic renal-cell carcinoma after nonmyeloblative allogeneic peripheral-blood stem-cell transplantation. NEJM. 2000, 343: 750-8.

  50. Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins c and e, beta carotene, and zinc for age-related macular degeneration and vision loss. Arch Opthalmol. 2001, 119: 1417-1436.

  51. Schmidt LS, Warren MB, Nickerson ML, et al. Birt-Hogg-Dube syndrome, a genodermatosis associated with spontaneous pneumothorax and kidney neoplasia, maps to chromosome 17p11.2. Am J Hum Genet. 2001, 69: 876-882.

  52. Kreitman RJ, Wilson WH, Bergeron K, et al. Efficacy of the anti-cd22 recombinant immunotoxin bl22 in chemotherapy-resistant hairy-cell l leukemia. NEJM. 2001, 345: 241-247.

  53. Oral EA, Simha V, Ruiz E, et al. Leptin-replacement therapy for lipodystrophy. NEJM. 2002, 346: 570-578. 

  54. Lee JS, Fitzgibbon E, Butman JA, et al. Normal vision despite narrowing of the optic canal in fibrous dysplasia. NEJM. 2002, 347: 1670-76.

  55. Kwong RY, Schussheim AE, Rekhraj, et al. Detecting acute coronary syndrome in the emergency department with cardiac magnetic resonance imaging. Circulation. 2003, 107: 531-37.

  56. Leibenluft E, Charney DS, Towbin KE, et al. Defining clinical phenotypes of juvenile mania. Am J Psychiatry. 2003, 160: 430-37.

  57. Kwong RY, Schussheim AE, Rekhraj S, et al. Detecting acute coronary syndrome in the emergency department with cardiac magnetic resonance imaging. Circulation. 2003, 107: 531-537.

  58. Oxman MN, Levin MJ, Johnson GR, et al. A Vaccine to Prevent Herpes Zoster and Postherpetic Neuralgia in Older Adults. N Engl J Med 2005;352:2271-84

  59. Wei MI, Toure I, Glenn GM, et al. Novel mutations in FH and expansion of the spectrum of phenotypes expressed in families with hereditary leiomyomatosis and renal cell cancer. J Med Genet. 2006, 43: 18-27. 

  60. Summers RM, Yao J, Pickhardt PJ, et al. Computed Tomographic Virtual Colonoscopy Computer-Aided Polyp Detection in a Screening Population. Gastroenterology. 2005, 129: 1832-44.

  61. Zarate CA, Singh JB, Carlson PJ, et al. A randomized trial of an n-methyl-d-aspartate antagonist in treatment-resistant major depression. Arch Gen Psychiatry. 2006, 63: 856-864.

  62. Pinto PA, Chung PH, Rastinehad AR, et al. Magnetic resonance imaging/ultrasound fusion guided prostate biopsy improves cancer cancer detection following transrectal ultrasound biopsy and correlates with multiparametric magnetic resonance imaging. J Urology. 2011, 186: 1281-5.

  63. Biesecker LG, Mullikin JC, Facio FM, et al. The ClinSeq Project: Piloting large-scale genome sequencing for research in genomic medicine. Genome Res. 2009, 19:1665-74.

  64. Johnson LA, Morgan RA, Dudley ME, et al. Gene Therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen. Blood. 2009, 114: 535-46.

  65. Aksentijevich I, Masters SL, Ferguson PJ, et al. An autoinflammatory disease with deficiency of the interleukin-1-recptor agonist. NEJM. 2009, 360: 2426-37.

  66. Kang K, Riazuddin S, Mundorff J, et al. Mutations in the lysosomal enzyme-targeting pathway and persistent stuttering. NEJM. 2010. 362:677-85.

  67. Kochenderfer JN, Zhiya Y, Frasheri D, et al. Adoptive transfer of syngeneic t cells transduced with a chimeric antigen receptor that recognizes murine cd19 can eradicate lymphoma and normal b cells. Blood. 2010, 116: 3875-886.

  68. Henderson WA, Rahim-Williams B, Kim KH, Sherwin LB, Abey SK, Martino AC, Fourie NH, Heitkemper MM, Zuccolotto AP. (2010). Validation of the Gastrointestinal Pain Pointer (GIPP) as a Measure of Symptom Severity in Persons With Abdominal Pain. Gastroenterol Nurs. 138(5), S-478.

  69. Robbins PF, Morgan RA, Feldman SA, et al. Tumor regression in patients with metastatic synovial cell sarcoma and melanoma using genetically engineered lymphocytes reactive with NY-ESO-1. J Clin Oncology. 2011, 29: 917-923.

  70. Rosenberg SA, Yang JC, Sherry RM, Kammula US, Hughes MS, Phan GQ, Citrin DE, Restifo NP, Robbins PF, Wunderlich JR, Morton KE, Laurencot CM, Steinberg SM, White DE, Dudley ME. (2011). Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy. Clin Cancer Res. 17(13), 4550-7.

  71. Sabatino M, Jiaqiang R, David-Ocampo V, et al. The establishment of a bank of stored bone marrow stromal cell products. Translational Med. 2012, 10:1-12.

  72. Baum BJ, Alevizos I, Zheng C, et al. Early responses to adenoviral-mediated transfer of the aquaporin-1 cdna for radiation-induced salivary hypofunction. PNAS. 2012, 109: 19403-7.

  73. Schelbert EB, Cao JJ, Sigurdsson S, et al. Prevalence and prognosis of unrecognized myocardial infarction determined by cardiac magnetic resonance in older adults. JAMA. 2012;308:890-97.

  74. Olnes MJ, Scheinberg P, Calvo KR, et al. Eltrombopag and improved hematopoiesis in refractory aplastic anemia. NEJM. 2012, 367: 11-19.

  75. Ratnayaka K, Faranesh AZ, Hansen MS, et al. Real-time mri-guided right heart catheterization adults using passive catheters. European Heart J. 2013, 34: 380-9.

  76. Snitkin ES, Zelazny AM, Thomas PJ, et al. Tracking a Hospital Outbreak of Carbapenem-Resistant Klebsiella pneumoniae with Whole-Genome Sequencing. Sci Transl Med. 2012, 148:1-9.

  77. Sibley CH, Plass N, Snow J, Wiggs EA, Brewer CC, King KA, Zalewski C, Kim HJ, Bishop R, Hill S, Paul SM, Kicker P, Phillips Z, Dolan JG, Widemann B, Jayaprakash N, Pucino F, Stone DL, Chapelle D, Snyder C, Butman JA, Wesley R, Goldbach-Mansky R. (2012). Sustained response and prevention of damage progression in patients with neonatal-onset multisystem inflammatory disease treated with anakinra: a cohort study to determine three- and five-year outcomes. Arthritis Rheum., 64(7), 2375-86.

  78. Cancer Genome Atlas Research Network et al. Comprehensive molecular characterization of clear cell renal cell carcinoma. Nature. 2013, 499: 43-9.

  79. Roschewski M, Dunleavy K, Pittaluga S, Moorhead M, Pepin F, Kong K, Shovlin M, Jaffe ES, Staudt LM, Lai C, Steinberg SM, Chen CC, Zheng J, Willis TD, Faham M, Wilson WH. (2015) Circulating tumour DNA and CT monitoring in patients with untreated diffuse large B-cell lymphoma: a correlative biomarker study. Lancet Oncology. 16(5), 541-9.

  80. Memoli MJ, Shaw PA, Han A, Czajkowski L, Reed S, Athota R, Bristol T, Fargis S, Risos K, Powers JH, Davey RT Jr, Taubenberger JK. (2016). Evaluation of Antihemagglutinin and Antineuraminidase Antibodies as Correlates of Protection in an Influenza A/H1N1 Virus Healthy Human Challenge Model. mBio. 7(2).

  81. Boyerinas B, Jochems C, Fantini M, Heery CR, Gulley JL, Tsang KY, Schlom J. (2015). Antibody-Dependent Cellular Cytotoxicity Activity of a Novel Anti-PD-L1 Antibody Avelumab (MSB0010718C) on Human Tumor Cells. Cancer Immunol Res. 3(10):1148-57.

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