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Head, Pulmonary Vascular Biology Section;
Co-Director, Translational Pulmonary Arterial Hypertension Program;
Assistant Director, 4D Lab
AB, Princeton University
MD, University of Chicago Pritzker School of Medicine
Dr. Jason Elinoff is currently a Tenure-Track Investigator in the NIH Clinical Center's Critical Care Medicine Department and serves as the Co-Director of the CCMD Translational Pulmonary Arterial Hypertension Program.
PAH is characterized by dysregulated cell proliferation and infiltration of activated inflammatory cells leading to progressive narrowing and obliteration of the distal pulmonary arteries. Persistent increases in pulmonary vascular resistance lead to right heart failure and ultimately death. While current therapeutics reduce pulmonary arterial pressure, and increase time to death or transplant, median survival is remains only five to seven years from the time of diagnosis. Unlike selective pulmonary vasodilators alone, approaches directed at inflammatory vascular remodeling have the potential to arrest or even reverse the disease.
Dr. Elinoff's research focus is the contributions of pulmonary vascular endothelium and immune effector cells to the development and progression of PAH. Current work includes in vitro profiling of human pulmonary artery endothelial cells with heterogeneous PAH-associated molecular defects in order to investigate molecular mechanisms that can exploited therapeutically. The overarching goal of the program is to translate basic science and pre-clinical studies to early phase therapeutic trials in PAH patients.
Dr. Elinoff earned his undergraduate degree in Chemistry from Princeton University and his degree in Medicine from the University of Chicago Pritzker School of Medicine. He went on to complete internship and residency training in Internal Medicine at the Massachusetts General Hospital.
Dr. Elinoff completed fellowship training in Critical Care Medicine at the NIH Clinical Center and Pulmonary and Critical Care Medicine at Johns Hopkins University.
Elinoff JM, Agarwal R, Barnett CF, Benza RL, Rosenzweig EB, Cuttica MJ, Gharib AM, Gray MP, Hassoun PM, Hemnes AR, Humbert M, Kolb TM, Lahm T, Leopold JA, Mathai SC, McLaughlin VV, Preston IR, Shlobin OA, Steen VD, Zamanian RT, Solomon MA. Challenges in Pulmonary Hypertension: Controversies in Treating the Tip of the Iceberg. Am J Respir Crit Care Med. 2018 Feb 9. [Epub ahead of print] PMID: 29425462
Elinoff JM, Chen LY, Dougherty EJ, Awad KS, Wang S, Biancotto A, Siddiqui AH, Weir NA, Cai R, Sun J, Preston IR, Solomon MA, Danner RL. Spironolactone-induced Degradation of the TFIIH Core Complex XPB Subunit Suppresses NF-kB and AP-1 Signaling. Cardiovasc Res. 2018;114(1):65-76. PMID: 29036418
Dougherty EJ, Elinoff JM, Ferreyra GA, Hou A, Cai R, Sun J, Blaine KP, Wang S, Danner RL. Mineralocorticoid Receptor (MR) Trans-Activation of Inflammation AP-1 Signaling: Dependence on DNA Sequence, MR Conformation, and AP-1 Family Member Expression. J Biol Chem. 2016;291(45):23628-23644. PMID: 27650495
Awad KS, Elinoff JM, Wang S, Gairhe S, Ferreyra GA, Cai R, Sun J, Solomon MA, Danner RL. Raf/ERK drives the proliferative and invasive phenotype of BMPR2-silenced pulmonary artery endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2016;310(2):L187-201. PMID: 26589479
Wang S, Awad KS, Elinoff JM, Dougherty EJ, Ferreyra GA, Wang JY, Cai R, Sun J, Ptasinska A, Danner RL. G Protein-Coupled Receptor 40 (GPR40) and Peroxisome Proliferator-Activated Receptor γ (PPARγ): An Integrated Two-Receptor Signaling Pathway. J Biol Chem. 2015;290(32):19544-57. PMID: 26105050
View a complete list of Dr. Elinoff's" publications.
- NIH Bench-to-Bedside Award, "Role of AR and ER Signaling in Pulmonary Arterial Hypertension", 2011
- NIH Clinical Center Director's Award, 2010
- Alpha Omega Alpha, University of Chicago Pritzker School of Medicine, 2004
- HHMI Continued Fellowship for Medical Studies 2003-2004
- HHMI-NIH Research Scholar 2002
- Everett S. Wallis Prize in Organic Chemistry, Princeton University, 1999
- Magna Cum Laude, Department of Chemistry, Princeton University, 1999
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This page last updated on 03/14/2019