NIH Bench-to-Bedside Program
The Bench-to-Bedside (BtB) Program funds research teams seeking to translate basic scientific findings into therapeutic interventions for patients and to increase understanding of important disease processes.
The BtB Program accomplishes this mission by addressing barriers, such as the traditional silos between basic and clinical researchers in biomedical research, which can hinder progress toward finding new therapeutics for patients in need.
BtB teams involve basic and clinical researchers, often from different NIH Institutes and Centers. In 2006, the BtB program's charge was expanded to unite the efforts of intramural and extramural NIH researchers. Intramural science refers to research that takes place on an NIH campus under the auspices of federal employees, while extramural research is funded by NIH and conducted by investigators and institutions outside of NIH.
The BtB program exemplifies the benefits associated with intramural – extramural collaborations; the extramural community gains access to the Clinical Center's unique resources, and the intramural community can pursue innovative research with extramural investigators.
Each BtB award provides up to $150,000 a year for two years. Projects, which are funded by various NIH offices and institutes*, have represented several research categories: AIDS, rare diseases, behavioral and social sciences, minority health and health disparities, women's health, rare diseases drug development, pharmacogenomics, and general. These categories may change from year to year so please look at the most recent announcement for the most current funding categories.
To date, approximately 800 principal and associate investigators have collaborated on 238 funded projects with approximately $53 million distributed in total Bench-to-Bedside funding. The introduction of extramural collaborations in 2006 has resulted in 157 partnerships at 90 institutions. Ninety-seven percent of BtB awards spanning the three most recent review cycles have involved extramural partners.
Bench to Bedside Report
An in-depth review of the BtB Program was completed in August 2014 and updated in September 2016. The report includes important historical data, program trends, and funding information gathered since BtB was expanded to foster collaborations between intramural and extramural investigators eight years ago.
- Slide 1 - Bench-to-Bedside
- Slide 2 - Dr. Frank Maldarelli discusses "New Bioinformatic Approach to Determining HIV Incidence"
- Slide 3 - Dr. Jack Yanovski discusses "FTO and Eating in the Absence of Hunger"
- Slide 4 - Dr. Joan Han discusses "WAGR Syndrome: Clinical Characterization and Correlation with Genotype"
- Slide 5 - Dr. Manfred Boehm discusses "Aneurysm Formation in Patients with Mutation of STAT3"
- Slide 6 - Dr. Michael Iadarola discusses "New Treatments for Intractable Pain"
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This page last updated on 04/01/2019